Considering additive effects of polypharmacy

Genome-wide prediction of maize single-cross performance, considering non-additive genetic effects.

The prediction of single-cross hybrids in maize is a promising technique for optimizing the use of financial resources in a breeding program. This study aimed to evaluate Genomic Best Linear Unbiased Predictors models for hybrid prediction and compare them with the Bayesian Ridge Regression, Bayes A, Bayesian LASSO, Bayes C, Bayes B, and Reproducing Kernel Hilbert Spaces Regression models, with...

The effects of polypharmacy in older adults.

Provide optimized antidepressant monotherapy with multiple drugs before considering antidepressant polypharmacy

Many patients with chronic or recurring major depressive disorder have suboptimal responses to the wide range of antidepressant medications available. When confronted with these patients, clinicians may augment the original antidepressant with other medications, including adjunctive treatment with a second or third antidepressant. Although it is a widely-used practice among psychiatrists and pr...

Mapping QTL with additive effects and additive x additive epistatic interactions for plant architecture in wheat (Triticum aestivum L.)

In bread wheat (Triticum aestivum L.), crop height is an important determinant of agronomic performance. To map QTLs with additive effects and additive×additive epistatic interactions, 148 recombinant inbred lines and their parents, (‘YecoraRojo’ and Iranian landrace (No. #49)) were evaluated under normal and water deficit conditions. The experiments were carried out on research farms of Mahaba...

The effects of pharmacist interventions on patients with polypharmacy

Polypharmacy, the state of being prescribed or taking more medications than clinically appropriate, can result in a variety of negative outcomes for both patients and healthcare facilities. These include negative outcomes such as adverse drug effects, hospitalizations, and poor patient health, as well as economic outcomes such as increased drug cost and costs associated with increased utilizati...